Interessi di ricerca:
1989-1990 Dipartimento di Biologia Cellulare e dello Sviluppo DBCS Palermo.
Isolation and characterization of HSP70-like genes in Streptomyces coelicolor. (supervisor A.M. Puglia)
1990-1991 European Molecular Biology Laboratory EMBL Heidelberg (Germany)
1992-1994 DBCS Palermo (Italy)
Analysis of activation mechanism of Ras genes in the yeast Saccharomyces cerevisiae
(PhD program, supervisor Prof. O. Fasano).
1995-1999 Consiglio Nazionale delle Ricerche C.N.R. Palermo.
Isolation and molecular characterization of allergen on Parietaria Judaica. (supervisor. Dr. D. Geraci)
1999-2004 Dipartimento di Biopatologia e Metodologie Biomediche di Palermo.
in vitro expression analysis of human phenylalanine hydroxylase and genotype phenotype relationship; research of candidate genes in autism spectrum disorder (, supervisor Prof. V. Romano) 2007- present. The university of Southern California and DiBiMed Diet and age-related diseases from bench to bedside.
lista delle pubblicazioni ultimi 4 anni:
Dietary restriction: could it be considered as speed bump on tumor progression road?. Cangemi A., Fanale D., Rinaldi G., Bazan V., Galvano A., Perez A., Barraco N., Massihnia D., Castiglia M., Vieni S., Bronte G., Mirisola M., Russo A. (2016). TUMOR BIOLOGY, ISSN: 1010-4283, doi: 10.1007/s13277-016-5044-8
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Health span.
Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD.
Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18.
PMID: 26094889
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Select item 25902704
Interventions to Slow Aging in Humans: Are We Ready?
Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.
Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22.
PMID: 25902704 Free PMC Article
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Select item 25883209
Longevity: epigenetic and biomolecular aspects.
Taormina G, Mirisola MG.
Biomol Concepts. 2015 Apr;6(2):105-17. doi: 10.1515/bmc-2014-0038.
PMID: 25883209
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Select item 24905167
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.
Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD.
Cell Stem Cell. 2014 Jun 5;14(6):810-23. doi: 10.1016/j.stem.2014.04.014.
PMID: 24905167 Free PMC Article
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Select item 24883306
Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity.
Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo VD.
Aging Cell. 2014 Jun;13(3):457-67. doi: 10.1111/acel.12202. Epub 2014 Mar 20.
PMID: 24649827 Free PMC Article
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Select item 24606898
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD.
Cell Metab. 2014 Mar 4;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006.
PMID: 24606898 Free PMC Article
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Select item 24516402
Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging.
Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD.
PLoS Genet. 2014 Feb 6;10(2):e1004113. doi: 10.1371/journal.pgen.1004113. eCollection 2014 Feb.
PMID: 24516402 Free PMC Article
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Select item 24164772
Approaches to study yeast cell aging and death.
Mirisola MG, Braun RJ, Petranovic D.
FEMS Yeast Res. 2014 Feb;14(1):109-18. doi: 10.1111/1567-1364.12112. Epub 2013 Nov 26. Review.
PMID: 24164772 Free Article
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Select item 23747240
A radical signal activates the epigenetic regulation of longevity.
Mirisola MG, Longo VD.
Cell Metab. 2013 Jun 4;17(6):812-3. doi: 10.1016/j.cmet.2013.05.015.
PMID: 23747240 Free Article
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Select item 23296677
Assessing chronological aging in Saccharomyces cerevisiae.
Hu J, Wei M, Mirisola MG, Longo VD.
Methods Mol Biol. 2013;965:463-72. doi: 10.1007/978-1-62703-239-1_30.
Mirisola MG and Longo VD. (2012)
Acetic acid and acidification accelerate chronological and replicative aging in yeast.
Cell cycle, 11, 3087-3096.
Jia Hu1, Min Wei1, Mario G. Mirisola2, and Valter D. Longo1(2012)
Assessing Chronological Aging in Saccharomyces cerevisiae
Cell Senescence, Methods, and Protocols
Series: Methods in Molecular Biology, Vol. 965
Galluzzi, L.; Vitale, I.; Kepp, O.; Kroemer, G. (Eds.)
Humana Press ISBN 978-1-62703-238-4
Mirisola MG, Longo VD (2011). Conserved role of Ras-GRFs in promoting aging: from yeast to mice.. AGING, vol. 3, p. 340-343, ISSN: 1945-4589